In collaboration with Klaus Dreisewerd (Institute for Medical Physics and Biophysics) a novel ion source was developed for atmospheric pressure mass spectrometry (S. König, A. Pirkl, K. Dreisewerd).

 
 
Since 1999 there is a successful collaboration with Xantec bioanalytics Münster using alternative surfaces for surface plasmon resonance and microaffinity capture mass spectrometry (MAC-MS). A special flow cell was developed to interface both techniques.

References: Grote, J., N. Dankbar, E. Gedig, and S. König A surface plasmon resonance / mass spectrometry interface Anal. Chem. 77, 4 (2005), 1157-1162; Internat. Biotechn. Lab. 2002, 20,1:10

rafael_jens004 
 
 
 

 
The team was extended by Rafal Marzalek, (Erasmus, University of Krakow), Oliver Kollas and Klaus Dreisewerd (Medical Physics and Biophysics) in 2006. This allowed comparative investigations of axial and orthogonal TOFs. In addition, IR-MALDI is tested with an ion trap.
 
Reference: König, S., Kollas, O., Dreisewerd, K.  Generation of highly-charged peptide and protein ions by atmospheric pressure matrix-assisted infrared laser desorption ionization ion trap mass spectrometry. Anal. Chem. (2007) 79, 14: 5484 -5488 
rafael_jens001
 
 
 
 
 
 
 
 
Institut für Pharmazeutische und Medizinische Chemie 
 
König, S., Hasche, A., Pallast, S., Krieglstein, J., Klumpp, S.  Detection of ATP-binding to growth factors.  JASMS (2008)  DOI: 10.1016/j.jasms.2007.10.010
 
 
 
 
Tessmer, N., König, S., Malkus, U., Reichelt, R., Pötter, M., Steinbüchel, A.  Heat-shock protein HspA mimics the function of phasins sensu strictu in recombinant strains of Escherichia coli accumulating polythioesters or polyhydroxyalkanoates.  Microbiology (2007) 153,2:366-374
 
Zeller, M., M. Pötter, A. Steinbüchel, F. Reinecke, W. I. Burkitt, P. Derrick, and S. König »Mass spectrometry identifies homologues of phasin PhaP1 protein of Ralstonia eutropha on polyhydroxybutyrate granules«, Biomacromolecular Mass Spectrometry 1, 1 (2005) 75-84
 
 

König, S., Mehlich, A.-M., Büllesbach, J., Michiels, N. »Allohormones in Lumbricus terrestris? Mass spectrometry of the setal gland product indicates possible role of ubiquitin« Invertebrate Reproduction & Dev. 49, 1-2 (2006) 103-111
SwissProt submission P84589
 
 
Bettina Zeiss, Ralph Pirow 
 
DGMS 2003 
König, S., M. Zeller, J. Grote, B. Zeis, and R. Paul »Identification and Sequencing of Daphnia magna Hemoglobins Using MALDI Peptide Mapping and cap– and nanoHPLC-MS/MS«
 
 
 
de novo Sequenzierung bei Champignon-Tyrosinase und Aureusidinsynthase